7AP4

Thermus thermophilus Aspartyl-tRNA Synthetase in Complex with Compound AspS7HMDDA

7AP4 の概要

• エントリーDOI: 10.2210/pdb7ap4/pdb
• 分子名称: Aspartate--tRNA(Asp) ligase, (3~{S})-3-azanyl-4-[[(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxysulfonylamino]-4-oxidanylidene-butanoic acid (3 entities in total)
• 機能のキーワード: protein-inhibitor complex, trna aminoacylation, ligase
• 由来する生物種: Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 133342.57

構造登録者

De Graef, S.,Pang, L.,Strelkov, S.V.,Weeks, S.D. (登録日: 2020-10-15, 公開日: 2020-12-09, 最終更新日: 2024-01-31)

• 主引用文献: Zhang, B.,Pang, L.,Nautiyal, M.,De Graef, S.,Gadakh, B.,Lescrinier, E.,Rozenski, J.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A.; Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.; Molecules, 25:-, 2020; PubMed: 33081246; DOI: 10.3390/molecules25204751

実験手法

X-RAY DIFFRACTION (2.15 Å)