7AP2

Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with Compound LeuS7HMDDA

7AP2 の概要

• エントリーDOI: 10.2210/pdb7ap2/pdb
• 分子名称: Leucine--tRNA ligase, 1,2-ETHANEDIOL, [(2~{R},3~{S},4~{R},5~{R})-5-[7-azanyl-5-(hydroxymethyl)benzimidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-4-methyl-pentanoyl]sulfamate, ... (6 entities in total)
• 機能のキーワード: protein-inhibitor complex, rossmann fold, trna synthetase, ligase
• 由来する生物種: Neisseria gonorrhoeae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 98886.72

構造登録者

Pang, L.,De Graef, S.,Strelkov, S.V.,Weeks, S.D. (登録日: 2020-10-15, 公開日: 2020-10-28, 最終更新日: 2024-01-31)

• 主引用文献: Zhang, B.,Pang, L.,Nautiyal, M.,De Graef, S.,Gadakh, B.,Lescrinier, E.,Rozenski, J.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A.; Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.; Molecules, 25:-, 2020; PubMed: 33081246; DOI: 10.3390/molecules25204751

実験手法

X-RAY DIFFRACTION (2.25 Å)