7AMS
Crystal structure of the complex of the KFN mutant of HuJovi-1 Fab with human TRBC2
Summary for 7AMS
Entry DOI | 10.2210/pdb7ams/pdb |
Descriptor | Human A6 T-cell receptor alpha chain, Human A6 T-cell receptor beta chain TRBC2, Human Jovi-1 Fab, KFN mutant, heavy chain, ... (8 entities in total) |
Functional Keywords | hujovi-1, monoclonal antibody, therapeutic antibody, human t-cell receptor, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 98900.80 |
Authors | Ferrari, M.,Bulek, A.,Bughda, R.,Jha, R.,Welin, M.,Svensson, A.,Logan, D.T.,Sewell, A.,Onuoha, S.,Pule, M. (deposition date: 2020-10-09, release date: 2022-04-20, Last modification date: 2022-04-27) |
Primary citation | Ferrari, M.,Baldan, V.,Wawrzyniecka, P.,Bulek, A.,Kinna, A.,Ma, B.,Bugda, R.,Akbar, Z.,Srivastava, S.,Ghongane, P.,Gannon, I.,Robson, M.,Sillibourne, J.,Jha, R.,Lim, W.,Hopkins, J.,Welin, M.,Surade, S.,Dyson, M.,McCafferty, J.,Cordoba, S.,Thomas, S.,Logan, D.,Sewell, A.,Maciocia, P.,Onuoha, S.,Pule, M. Structure-Guided Engineering of Immunotherapies Targeting TRBC1 and TRBC2 in T Cell Malignancies Res Sq, 2022 Cited by DOI: 10.21203/rs.3.rs-1475171/v1PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.419 Å) |
Structure validation
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