7ALV

Crystal Structure of NLRP3 NACHT domain in complex with a potent inhibitor

7ALV の概要

• エントリーDOI: 10.2210/pdb7alv/pdb
• 分子名称: NACHT, LRR and PYD domains-containing protein 3, 1-[4-chloranyl-2,6-di(propan-2-yl)phenyl]-3-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-urea, ADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: inflammasome, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 65026.46

構造登録者

Dekker, C.,Hinniger, A. (登録日: 2020-10-07, 公開日: 2021-10-20, 最終更新日: 2024-01-31)

• 主引用文献: Dekker, C.,Mattes, H.,Wright, M.,Boettcher, A.,Hinniger, A.,Hughes, N.,Kapps-Fouthier, S.,Eder, J.,Erbel, P.,Stiefl, N.,Mackay, A.,Farady, C.J.; Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition.; J.Mol.Biol., 433:167309-167309, 2021; PubMed: 34687713; DOI: 10.1016/j.jmb.2021.167309

実験手法

X-RAY DIFFRACTION (2.835 Å)