7AKR

Human ADP-ribosylserine hydrolase ARH3 mutant E41A in complex with ADP-ribose dimer

This is a non-PDB format compatible entry.

Summary for 7AKR

• Entry DOI: 10.2210/pdb7akr/pdb
• Descriptor: ADP-ribose glycohydrolase ARH3, MAGNESIUM ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (6 entities in total)
• Functional Keywords: adp-ribosylation, adp-ribose, adprhl2, adp-ribosylhydrolase like 2, ser-adpr, serine-adpr, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 157042.15

Authors

Ariza, A. (deposition date: 2020-10-02, release date: 2021-06-16, Last modification date: 2024-01-31)

• Primary citation: Rack, J.G.M.,Liu, Q.,Zorzini, V.,Voorneveld, J.,Ariza, A.,Honarmand Ebrahimi, K.,Reber, J.M.,Krassnig, S.C.,Ahel, D.,van der Marel, G.A.,Mangerich, A.,McCullagh, J.S.O.,Filippov, D.V.,Ahel, I.; Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal.; Nat Commun, 12:4581-4581, 2021; PubMed: 34321462; DOI: 10.1038/s41467-021-24723-3

Experimental method

X-RAY DIFFRACTION (1.95 Å)