7AK3

CLK1 bound with CAF052

Summary for 7AK3

Entry DOI	10.2210/pdb7ak3/pdb
Descriptor	Dual specificity protein kinase CLK1, ~{N}-[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine (3 entities in total)
Functional Keywords	clk1, kinase, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	39985.96
Authors	Schroeder, M.,Chaikuad, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-09-29, release date: 2020-11-11, Last modification date: 2024-01-31)
Primary citation	Schroder, M.,Filippakopoulos, P.,Schwalm, M.P.,Ferrer, C.A.,Drewry, D.H.,Knapp, S.,Chaikuad, A. Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3. Int J Mol Sci, 21:-, 2020 Cited by PubMed: 33114754 DOI: 10.3390/ijms21217953 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation