7AK3

CLK1 bound with CAF052

7AK3 の概要

• エントリーDOI: 10.2210/pdb7ak3/pdb
• 分子名称: Dual specificity protein kinase CLK1, ~{N}-[3-fluoranyl-4-(4-methylpiperazin-1-yl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine (3 entities in total)
• 機能のキーワード: clk1, kinase, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39985.96

構造登録者

Schroeder, M.,Chaikuad, A.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-09-29, 公開日: 2020-11-11, 最終更新日: 2024-01-31)

• 主引用文献: Schroder, M.,Filippakopoulos, P.,Schwalm, M.P.,Ferrer, C.A.,Drewry, D.H.,Knapp, S.,Chaikuad, A.; Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3.; Int J Mol Sci, 21:-, 2020; PubMed: 33114754; DOI: 10.3390/ijms21217953

実験手法

X-RAY DIFFRACTION (2.5 Å)