7AH3

Kinase domain of cSrc in complex with a pyrazolopyrimidine

Summary for 7AH3

• Entry DOI: 10.2210/pdb7ah3/pdb
• Descriptor: Proto-oncogene tyrosine-protein kinase Src, ~{N}-[(2-fluorophenyl)methyl]-6-(morpholin-4-ylmethylsulfanyl)-1-(2-phenylethyl)pyrazolo[3,4-d]pyrimidin-4-amine, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: kinase domain substituted pyrazolopyrimidine inhibitor complex c-src inhibitor, oncoprotein
• Biological source: Gallus gallus (Chicken)
• Total number of polymer chains: 2
• Total formula weight: 66921.05

Authors

Dello Iacono, L.,Kleinboelting, S.,Fallacara, A.L.,Rauh, D. (deposition date: 2020-09-24, release date: 2021-10-06, Last modification date: 2024-01-31)

• Primary citation: Dello Iacono, L.,Kleinboelting, S.,Passannanti, R.,Fallacara, A.L.,Di Pisa, F.,Richters, A.,Musumeci, F.,Rauh, D.,Schenone, S.,Botta, M.; Insights into the binding of pyrazolopyrimidines to Src kinase; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)