7AH3

Kinase domain of cSrc in complex with a pyrazolopyrimidine

7AH3 の概要

• エントリーDOI: 10.2210/pdb7ah3/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, ~{N}-[(2-fluorophenyl)methyl]-6-(morpholin-4-ylmethylsulfanyl)-1-(2-phenylethyl)pyrazolo[3,4-d]pyrimidin-4-amine, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: kinase domain substituted pyrazolopyrimidine inhibitor complex c-src inhibitor, oncoprotein
• 由来する生物種: Gallus gallus (Chicken)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66921.05

構造登録者

Dello Iacono, L.,Kleinboelting, S.,Fallacara, A.L.,Rauh, D. (登録日: 2020-09-24, 公開日: 2021-10-06, 最終更新日: 2024-01-31)

• 主引用文献: Dello Iacono, L.,Kleinboelting, S.,Passannanti, R.,Fallacara, A.L.,Di Pisa, F.,Richters, A.,Musumeci, F.,Rauh, D.,Schenone, S.,Botta, M.; Insights into the binding of pyrazolopyrimidines to Src kinase; To Be Published,

実験手法

X-RAY DIFFRACTION (1.95 Å)