7AG5

Structure of the Laspartomycin C double mutant G4D D-allo-Thr9D-Dap in complex with Geranyl phosphate

7AG5 の概要

• エントリーDOI: 10.2210/pdb7ag5/pdb
• 分子名称: Laspartomycin C double mutant G4D D-allo-Thr9D-Dap, CALCIUM ION, Geranyl phosphate, ... (5 entities in total)
• 機能のキーワード: antibiotic, calcium-dependent antibiotic, bacterial cell wall biosynthesis inhibitor, lipopeptide antibiotic
• 由来する生物種: Streptomyces viridochromogenes
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 1641.85

構造登録者

Zeronian, M.R.,Pearce, N.M.,Wood, T.M.,Martin, N.I.,Janssen, B.J.C. (登録日: 2020-09-21, 公開日: 2022-02-02, 最終更新日: 2024-01-31)

• 主引用文献: Wood, T.M.,Zeronian, M.R.,Buijs, N.,Bertheussen, K.,Abedian, H.K.,Johnson, A.V.,Pearce, N.M.,Lutz, M.,Kemmink, J.,Seirsma, T.,Hamoen, L.W.,Janssen, B.J.C.,Martin, N.I.; Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures; Chem Sci, 13:2985-2991, 2022; DOI: 10.1039/D1SC07190D

実験手法

X-RAY DIFFRACTION (1.04 Å)