Summary for 7AEL
Entry DOI | 10.2210/pdb7ael/pdb |
Descriptor | Alpha-1-antitrypsin, ~{N}-[(1~{S},2~{R})-1-(3-fluoranyl-2-methyl-phenyl)-1-oxidanyl-pentan-2-yl]-2-oxidanylidene-1,3-dihydroindole-4-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | serpin, serine protease inhibitor, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 46062.16 |
Authors | Chung, C. (deposition date: 2020-09-17, release date: 2021-03-10, Last modification date: 2024-05-01) |
Primary citation | Lomas, D.A.,Irving, J.A.,Arico-Muendel, C.,Belyanskaya, S.,Brewster, A.,Brown, M.,Chung, C.W.,Dave, H.,Denis, A.,Dodic, N.,Dossang, A.,Eddershaw, P.,Klimaszewska, D.,Haq, I.,Holmes, D.S.,Hutchinson, J.P.,Jagger, A.M.,Jakhria, T.,Jigorel, E.,Liddle, J.,Lind, K.,Marciniak, S.J.,Messer, J.,Neu, M.,Olszewski, A.,Ordonez, A.,Ronzoni, R.,Rowedder, J.,Rudiger, M.,Skinner, S.,Smith, K.J.,Terry, R.,Trottet, L.,Uings, I.,Wilson, S.,Zhu, Z.,Pearce, A.C. Development of a small molecule that corrects misfolding and increases secretion of Z alpha 1 -antitrypsin. Embo Mol Med, 13:e13167-e13167, 2021 Cited by PubMed: 33512066DOI: 10.15252/emmm.202013167 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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