7ACH
CRYSTAL STRUCTURE OF ACTIVE KRAS G12D (GPPCP) IN COMPLEX WITH THE SOAKED DIMERIC INHIBITOR BI-5747
Summary for 7ACH
Entry DOI | 10.2210/pdb7ach/pdb |
Descriptor | GTPase KRas, (3~{S})-5-oxidanyl-3-[2-[[6-[[3-[(1~{S})-6-oxidanyl-3-oxidanylidene-1,2-dihydroisoindol-1-yl]-1~{H}-indol-2-yl]methylamino]hexylamino]methyl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... (5 entities in total) |
Functional Keywords | vienna, ppi, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 40533.51 |
Authors | Kessler, D. (deposition date: 2020-09-10, release date: 2020-11-18, Last modification date: 2024-01-31) |
Primary citation | Kessler, D. CRYSTAL STRUCTURE OF ACTIVE KRAS G12D (GPPCP) IN COMPLEX WITH THE SOAKED DIMERIC INHIBITOR BI-5747 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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