7ABS

Structure of human DCLRE1C/Artemis in complex with DNA - re-evaluation of 6WO0

7ABS の概要

• エントリーDOI: 10.2210/pdb7abs/pdb
• 分子名称: Protein artemis, DNA (5'-D(P*GP*CP*GP*AP*TP*CP*AP*GP*CP*T)-3'), DNA (5'-D(*CP*AP*GP*C)-3'), ... (5 entities in total)
• 機能のキーワード: artemis, nhej, nuclease, lyase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 50472.49

構造登録者

Newman, J.A.,Yosaatmadja, Y.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (登録日: 2020-09-08, 公開日: 2021-08-04, 最終更新日: 2024-01-31)

• 主引用文献: Yosaatmadja, Y.,Baddock, H.T.,Newman, J.A.,Bielinski, M.,Gavard, A.E.,Mukhopadhyay, S.M.M.,Dannerfjord, A.A.,Schofield, C.J.,McHugh, P.J.,Gileadi, O.; Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.; Nucleic Acids Res., 49:9310-9326, 2021; PubMed: 34387696; DOI: 10.1093/nar/gkab693

実験手法

X-RAY DIFFRACTION (1.97 Å)