7A9D

Crystal structure of H12 Haemagglutinin

Summary for 7A9D

• Entry DOI: 10.2210/pdb7a9d/pdb
• Descriptor: Hemagglutinin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: receptor binding, fusion of virus membrane with host plasma membrane., viral protein
• Biological source: Influenza A virus (A/duck/Alberta/60/1976(H12N5)); More
• Total number of polymer chains: 4
• Total formula weight: 113148.40

Authors

Xiong, X.,Walker, P.,Zhang, J.,Gamblin, S.,Skehel, J.J. (deposition date: 2020-09-01, release date: 2020-12-02, Last modification date: 2024-01-31)

Primary citation

Gamblin, S.J.,Vachieri, S.G.,Xiong, X.,Zhang, J.,Martin, S.R.,Skehel, J.J.
Hemagglutinin Structure and Activities.
Cold Spring Harb Perspect Med, 11:-, 2021

PubMed Abstract: Hemagglutinins (HAs) are the receptor-binding and membrane fusion glycoproteins of influenza viruses. They recognize sialic acid-containing, cell-surface glycoconjugates as receptors but have limited affinity for them, and, as a consequence, virus attachment to cells requires their interaction with several virus HAs. Receptor-bound virus is transferred into endosomes where membrane fusion by HAs is activated at pH between 5 and 6.5, depending on the strain of virus. Fusion activity requires extensive rearrangements in HA conformation that include extrusion of a buried "fusion peptide" to connect with the endosomal membrane, form a bridge to the virus membrane, and eventually bring both membranes close together. In this review, we give an overview of the structures of the 16 genetically and antigenically distinct subtypes of influenza A HA in relation to these two functions in virus replication and in relation to recognition of HA by antibodies that neutralize infection.

PubMed: 32513673
DOI: 10.1101/cshperspect.a038638

Experimental method

X-RAY DIFFRACTION (2.7 Å)