7A9D

Crystal structure of H12 Haemagglutinin

7A9D の概要

• エントリーDOI: 10.2210/pdb7a9d/pdb
• 分子名称: Hemagglutinin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: receptor binding, fusion of virus membrane with host plasma membrane., viral protein
• 由来する生物種: Influenza A virus (A/duck/Alberta/60/1976(H12N5)); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 113148.40

構造登録者

Xiong, X.,Walker, P.,Zhang, J.,Gamblin, S.,Skehel, J.J. (登録日: 2020-09-01, 公開日: 2020-12-02, 最終更新日: 2024-11-13)

主引用文献

Gamblin, S.J.,Vachieri, S.G.,Xiong, X.,Zhang, J.,Martin, S.R.,Skehel, J.J.
Hemagglutinin Structure and Activities.
Cold Spring Harb Perspect Med, 11:-, 2021

PubMed Abstract: Hemagglutinins (HAs) are the receptor-binding and membrane fusion glycoproteins of influenza viruses. They recognize sialic acid-containing, cell-surface glycoconjugates as receptors but have limited affinity for them, and, as a consequence, virus attachment to cells requires their interaction with several virus HAs. Receptor-bound virus is transferred into endosomes where membrane fusion by HAs is activated at pH between 5 and 6.5, depending on the strain of virus. Fusion activity requires extensive rearrangements in HA conformation that include extrusion of a buried "fusion peptide" to connect with the endosomal membrane, form a bridge to the virus membrane, and eventually bring both membranes close together. In this review, we give an overview of the structures of the 16 genetically and antigenically distinct subtypes of influenza A HA in relation to these two functions in virus replication and in relation to recognition of HA by antibodies that neutralize infection.

PubMed: 32513673
DOI: 10.1101/cshperspect.a038638

実験手法

X-RAY DIFFRACTION (2.7 Å)