7A7G

Soluble epoxide hydrolase in complex with TK90

Summary for 7A7G

• Entry DOI: 10.2210/pdb7a7g/pdb
• Descriptor: Bifunctional epoxide hydrolase 2, (2~{R})-2-[[4-[[4-methoxy-2-(trifluoromethyl)phenyl]methylcarbamoyl]phenyl]methyl]butanoic acid (3 entities in total)
• Functional Keywords: complex, structural genomics, structural genomics consortium, sgc, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 80115.86

Authors

Ni, X.,Kramer, J.S.,Kirchner, T.,Proschak, E.,Chaikuad, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-08-28, release date: 2021-08-04, Last modification date: 2024-01-31)

• Primary citation: Hartmann, M.,Bibli, S.I.,Tews, D.,Ni, X.,Kircher, T.,Kramer, J.S.,Kilu, W.,Heering, J.,Hernandez-Olmos, V.,Weizel, L.,Scriba, G.K.E.,Krait, S.,Knapp, S.,Chaikuad, A.,Merk, D.,Fleming, I.,Fischer-Posovszky, P.,Proschak, E.; Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPAR gamma Modulator.; J.Med.Chem., 64:2815-2828, 2021; PubMed: 33620196; DOI: 10.1021/acs.jmedchem.0c02063

Experimental method

X-RAY DIFFRACTION (2.4 Å)