7A6Q

Crystal structure of human aldehyde dehydrogenase 1A3 in complex with selective NR6 inhibitor compound

7A6Q の概要

• エントリーDOI: 10.2210/pdb7a6q/pdb
• 分子名称: Aldehyde dehydrogenase family 1 member A3, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile, ... (7 entities in total)
• 機能のキーワード: dehydrogenase isoenzyme aldh1a3 selective inhibitor high grade glioma, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115156.74

構造登録者

Gelardi, E.L.M.,Garavaglia, S. (登録日: 2020-08-26, 公開日: 2021-02-17, 最終更新日: 2024-01-31)

• 主引用文献: Gelardi, E.L.M.,Colombo, G.,Picarazzi, F.,Ferraris, D.M.,Mangione, A.,Petrarolo, G.,Aronica, E.,Rizzi, M.,Mori, M.,La Motta, C.,Garavaglia, S.; A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro.; Cancers (Basel), 13:-, 2021; PubMed: 33478031; DOI: 10.3390/cancers13020356

実験手法

X-RAY DIFFRACTION (2.95 Å)