7A6K

Crystal Structure of EGFR-T790M/V948R in Complex with TAK-788

Summary for 7A6K

Entry DOI	10.2210/pdb7a6k/pdb
Descriptor	Epidermal growth factor receptor, propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate, SULFATE ION, ... (4 entities in total)
Functional Keywords	egfr, t790m/v948r, exon20, covalent, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	154878.93
Authors	Niggenaber, J.,Mueller, M.P.,Rauh, D. (deposition date: 2020-08-25, release date: 2022-02-23, Last modification date: 2024-01-31)
Primary citation	Lategahn, J.,Tumbrink, H.L.,Schultz-Fademrecht, C.,Heimsoeth, A.,Werr, L.,Niggenaber, J.,Keul, M.,Parmaksiz, F.,Baumann, M.,Menninger, S.,Zent, E.,Landel, I.,Weisner, J.,Jeyakumar, K.,Heyden, L.,Russ, N.,Muller, F.,Lorenz, C.,Bragelmann, J.,Spille, I.,Grabe, T.,Muller, M.P.,Heuckmann, J.M.,Klebl, B.M.,Nussbaumer, P.,Sos, M.L.,Rauh, D. Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. J.Med.Chem., 65:6643-6655, 2022 Cited by PubMed: 35486541 DOI: 10.1021/acs.jmedchem.1c02080 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation