7A6K

Crystal Structure of EGFR-T790M/V948R in Complex with TAK-788

7A6K の概要

• エントリーDOI: 10.2210/pdb7a6k/pdb
• 分子名称: Epidermal growth factor receptor, propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: egfr, t790m/v948r, exon20, covalent, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 154878.93

構造登録者

Niggenaber, J.,Mueller, M.P.,Rauh, D. (登録日: 2020-08-25, 公開日: 2022-02-23, 最終更新日: 2024-01-31)

• 主引用文献: Lategahn, J.,Tumbrink, H.L.,Schultz-Fademrecht, C.,Heimsoeth, A.,Werr, L.,Niggenaber, J.,Keul, M.,Parmaksiz, F.,Baumann, M.,Menninger, S.,Zent, E.,Landel, I.,Weisner, J.,Jeyakumar, K.,Heyden, L.,Russ, N.,Muller, F.,Lorenz, C.,Bragelmann, J.,Spille, I.,Grabe, T.,Muller, M.P.,Heuckmann, J.M.,Klebl, B.M.,Nussbaumer, P.,Sos, M.L.,Rauh, D.; Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.; J.Med.Chem., 65:6643-6655, 2022; PubMed: 35486541; DOI: 10.1021/acs.jmedchem.1c02080

実験手法

X-RAY DIFFRACTION (2 Å)