7A5Z

Structure of VIM-2 metallo-beta-lactamase with hydrolysed Faropenem imine product

Summary for 7A5Z

Entry DOI	10.2210/pdb7a5z/pdb
Descriptor	Beta-lactamase VIM-2, (5~{Z})-2-[1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-5-(4-oxidanylbutylidene)-2~{H}-1,3-thiazole-4-carboxylic acid, ZINC ION, ... (7 entities in total)
Functional Keywords	metallo-beta-lactamase, vim-2, faropenem, antimicrobial resistance, penems, carbapenems, antimicrobial protein
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	1
Total formula weight	26311.25
Authors	Lucic, A.,Schofield, C.J. (deposition date: 2020-08-24, release date: 2021-02-24, Last modification date: 2024-01-31)
Primary citation	Lucic, A.,Hinchliffe, P.,Malla, T.R.,Tooke, C.L.,Brem, J.,Calvopina, K.,Lohans, C.T.,Rabe, P.,McDonough, M.A.,Armistead, T.,Orville, A.M.,Spencer, J.,Schofield, C.J. Faropenem reacts with serine and metallo-beta-lactamases to give multiple products. Eur.J.Med.Chem., 215:113257-113257, 2021 Cited by PubMed: 33618159 DOI: 10.1016/j.ejmech.2021.113257 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.29 Å)

Structure validation