7A5R

Complex of SARS-CoV-2 spike and CR3022 Fab (Non-Uniform Refinement)

7A5R の概要

• エントリーDOI: 10.2210/pdb7a5r/pdb
• EMDBエントリー: 11648
• 分子名称: CR3022 Fab Heavy Chain, CR3022 Fab Light Chain, Spike glycoprotein, ... (4 entities in total)
• 機能のキーワード: sars-cov-2, antibody, viral protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 393233.51

構造登録者

Wrobel, A.G.,Benton, D.J.,Rosenthal, P.B.,Gamblin, S.J. (登録日: 2020-08-21, 公開日: 2020-09-16, 最終更新日: 2020-11-04)

主引用文献

Wrobel, A.G.,Benton, D.J.,Hussain, S.,Harvey, R.,Martin, S.R.,Roustan, C.,Rosenthal, P.B.,Skehel, J.J.,Gamblin, S.J.
Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein.
Nat Commun, 11:5337-5337, 2020

PubMed Abstract: The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.

PubMed: 33087721
DOI: 10.1038/s41467-020-19146-5

実験手法

ELECTRON MICROSCOPY (3.7 Å)