7A5N

Structure of DYRK1A in complex with compound 34

7A5N の概要

• エントリーDOI: 10.2210/pdb7a5n/pdb
• 関連するPDBエントリー: 7a4o 7a4r 7a4s 7a4w 7a4z 7a51 7a52 7a53 7a55 7a5b 7a5d 7a8l
• 分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, 5-(2-azanylpyridin-4-yl)-~{N}-[[2,6-bis(fluoranyl)phenyl]methyl]-2-methyl-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: serine/threonine-protein kinase, phosphoprotein, kinase, sbdd, fbld, small molecule inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84133.35

構造登録者

Dokurno, P.,Surgenor, A.E.,Hubbard, R.E. (登録日: 2020-08-21, 公開日: 2021-06-30, 最終更新日: 2024-01-31)

• 主引用文献: Lee Walmsley, D.,Murray, J.B.,Dokurno, P.,Massey, A.J.,Benwell, K.,Fiumana, A.,Foloppe, N.,Ray, S.,Smith, J.,Surgenor, A.E.,Edmonds, T.,Demarles, D.,Burbridge, M.,Cruzalegui, F.,Kotschy, A.,Hubbard, R.E.; Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B.; J.Med.Chem., 64:8971-8991, 2021; PubMed: 34143631; DOI: 10.1021/acs.jmedchem.1c00024

実験手法

X-RAY DIFFRACTION (2.3 Å)