7A21

Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2158

Summary for 7A21

• Entry DOI: 10.2210/pdb7a21/pdb
• Descriptor: Activin receptor type I, 4-methyl-3-[4-(pyrrolidin-1-ylmethyl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine, DIMETHYL SULFOXIDE, ... (5 entities in total)
• Functional Keywords: kinase, inhibitor complex, receptor, signaling protein, bmp
• Biological source: Homo sapiens
• Total number of polymer chains: 2
• Total formula weight: 70192.72

Authors

Adamson, R.J.,Williams, E.P.,Smil, D.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2020-08-14, release date: 2020-09-16, Last modification date: 2024-01-31)

• Primary citation: Adamson, R.J.,Williams, E.P.,Smil, D.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N.; Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2153; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.14 Å)