7A14

CRYSTAL STRUCTURE OF HUMAN METHIONINE AMINOPEPTIDASE-2 IN COMPLEX WITH AN INHIBITOR GSK2218325A (COMPOUND 32)

7A14 の概要

• エントリーDOI: 10.2210/pdb7a14/pdb
• 分子名称: Methionine aminopeptidase 2, PHOSPHATE ION, 5-chloranyl-6-fluoranyl-3-(2-propan-2-yloxyphenyl)-1~{H}-indole-2-carboxamide, ... (5 entities in total)
• 機能のキーワード: methionine aminopeptidase-2, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42631.60

構造登録者

Thorpe, J.H. (登録日: 2020-08-11, 公開日: 2020-09-23, 最終更新日: 2024-01-31)

• 主引用文献: Hirst, D.J.,Brandt, M.,Bruton, G.,Christodoulou, E.,Cutler, L.,Deeks, N.,Goodacre, J.D.,Jack, T.,Lindon, M.,Miah, A.,Page, K.,Parr, N.,Shukla, L.,Sims, M.,Thomas, P.,Thorpe, J.,Holmes, D.S.; Structure-based optimisation of orally active & reversible MetAP-2 inhibitors maintaining a tight 'molecular budget'.; Bioorg.Med.Chem.Lett., 30:127533-127533, 2020; PubMed: 32919012; DOI: 10.1016/j.bmcl.2020.127533

実験手法

X-RAY DIFFRACTION (2.14 Å)