7A10

LppS with covalent adduct derived from 1g

Summary for 7A10

• Entry DOI: 10.2210/pdb7a10/pdb
• Related: 7A0Z
• Descriptor: L,D-transpeptidase 2, 4-methoxycyclohexa-2,5-diene-1-thione (3 entities in total)
• Functional Keywords: transpeptidase, cell wall, peptidoglycan, antibiotic, beta-lactam, covalent inhibitor, mycobacterium tuberculosis, ligase
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 2
• Total formula weight: 57301.73

Authors

Schnell, R.,Steiner, E.M. (deposition date: 2020-08-11, release date: 2021-04-21, Last modification date: 2024-01-31)

• Primary citation: Martelli, G.,Pessatti, T.B.,Steiner, E.M.,Cirillo, M.,Caso, C.,Bisognin, F.,Landreh, M.,Monte, P.D.,Giacomini, D.,Schnell, R.; N-Thio-beta-lactams targeting L,D-transpeptidase-2, with activity against drug-resistant strains of Mycobacterium tuberculosis.; Cell Chem Biol, 28:1321-, 2021; PubMed: 33826941; DOI: 10.1016/j.chembiol.2021.03.008

Experimental method

X-RAY DIFFRACTION (1.85 Å)