7ZLU
Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum in complex with UDP-2-deoxy-2-fluoro-D-glucose
Summary for 7ZLU
Entry DOI | 10.2210/pdb7zlu/pdb |
Related | 6FSN 7ZHB 7ZKC 7ZLE 7ZLL |
Descriptor | UDP-glucose-glycoprotein glucosyltransferase-like protein, 2-acetamido-2-deoxy-beta-D-glucopyranose, URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE, ... (6 entities in total) |
Functional Keywords | glycoprotein, misfolding, transferase, endoplasmic reticulum, udp-2-deoxy-2-fluoro-d-glucose, gt24 |
Biological source | Chaetomium thermophilum |
Total number of polymer chains | 3 |
Total formula weight | 108350.28 |
Authors | Roversi, P.,Zitzmann, N.,Bayo, Y.,Ibba, R. (deposition date: 2022-04-15, release date: 2022-06-22, Last modification date: 2024-01-31) |
Primary citation | Guay, K.P.,Ibba, R.,Kiappes, J.L.,Vasiljevic, S.,Boni, F.,De Benedictis, M.,Zeni, I.,Le Cornu, J.D.,Hensen, M.,Chandran, A.V.,Kantsadi, A.L.,Caputo, A.T.,Blanco Capurro, J.I.,Bayo, Y.,Hill, J.C.,Hudson, K.,Lia, A.,Brun, J.,Withers, S.G.,Marti, M.,Biasini, E.,Santino, A.,De Rosa, M.,Milani, M.,Modenutti, C.P.,Hebert, D.N.,Zitzmann, N.,Roversi, P. A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint. Iscience, 26:107919-107919, 2023 Cited by PubMed: 37822503DOI: 10.1016/j.isci.2023.107919 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.049 Å) |
Structure validation
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