7YQ9
Crystal structure of BRD4 bromodomain 1 (BD1) in complex with N-[2-(1H-indol-3-yl)ethyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-amine
Summary for 7YQ9
Entry DOI | 10.2210/pdb7yq9/pdb |
Descriptor | Bromodomain-containing protein 4, CHLORIDE ION, N-[2-(1H-indol-3-yl)ethyl]-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-amine, ... (5 entities in total) |
Functional Keywords | brd4, bet inhibitor, complex, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 30906.05 |
Authors | |
Primary citation | Kim, J.H.,Pandit, N.,Yoo, M.,Park, T.H.,Choi, J.U.,Park, C.H.,Jung, K.Y.,Lee, B.I. Crystal structure of [1,2,4]triazolo[4,3-b]pyridazine derivatives as BRD4 bromodomain inhibitors and structure-activity relationship study. Sci Rep, 13:10805-10805, 2023 Cited by PubMed: 37402749DOI: 10.1038/s41598-023-37527-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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