7YC1
Crystal structure of FGFR4 kinase domain with 10d
Summary for 7YC1
Entry DOI | 10.2210/pdb7yc1/pdb |
Descriptor | Fibroblast growth factor receptor 4, ~{N}-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-1-propyl-pyrrolo[3,2-b]pyridine-3-carboxamide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | kinase, inhibitor, structural protein, transferase-transferase inhibitor complex, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35481.78 |
Authors | Chen, X.J.,Lin, Q.M.,Chen, Y.H. (deposition date: 2022-06-30, release date: 2022-11-16, Last modification date: 2023-11-29) |
Primary citation | Yang, F.,Chen, X.,Song, X.,Ortega, R.,Lin, X.,Deng, W.,Guo, J.,Tu, Z.,Patterson, A.V.,Smaill, J.B.,Chen, Y.,Lu, X. Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. J.Med.Chem., 65:14809-14831, 2022 Cited by PubMed: 36278929DOI: 10.1021/acs.jmedchem.2c01319 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.535 Å) |
Structure validation
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