7YBO
Crystal structure of FGFR4 kinase domain with 10z
Summary for 7YBO
Entry DOI | 10.2210/pdb7ybo/pdb |
Descriptor | Fibroblast growth factor receptor 4, ~{N}-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, structural protein, transferase-transferase inhibitor complex, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35944.78 |
Authors | Chen, X.J.,Lin, Q.M.,Chen, Y.H. (deposition date: 2022-06-29, release date: 2022-11-16, Last modification date: 2023-11-29) |
Primary citation | Yang, F.,Chen, X.,Song, X.,Ortega, R.,Lin, X.,Deng, W.,Guo, J.,Tu, Z.,Patterson, A.V.,Smaill, J.B.,Chen, Y.,Lu, X. Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors. J.Med.Chem., 65:14809-14831, 2022 Cited by PubMed: 36278929DOI: 10.1021/acs.jmedchem.2c01319 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.307 Å) |
Structure validation
Download full validation report