7Y3S

Controlling fibrosis using compound with novel binding mode to prolyl-tRNA synthetase 1

Summary for 7Y3S

Entry DOI	10.2210/pdb7y3s/pdb
Descriptor	Bifunctional glutamate/proline--tRNA ligase, 1-(6-bromanyl-7-methyl-imidazo[4,5-b]pyridin-3-yl)-3-[(2R,3S)-3-oxidanylpiperidin-2-yl]propan-2-one, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
Functional Keywords	prolyl-trna synthetase, inhibitor, fibrosis, binding mode, translation, translation-inhibitor complex, translation/inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	115263.04
Authors	Kim, S.,Yoon, I.,Son, J.,Park, S.,Hwang, K.Y. (deposition date: 2022-06-12, release date: 2023-07-05, Last modification date: 2023-11-29)
Primary citation	Yoon, I.,Kim, S.,Cho, M.,You, K.A.,Son, J.,Lee, C.,Suh, J.H.,Bae, D.J.,Kim, J.M.,Oh, S.,Park, S.,Kim, S.,Cho, S.H.,Park, S.,Bang, K.,Seo, M.,Kim, J.H.,Lee, B.,Park, J.S.,Hwang, K.Y.,Kim, S. Control of fibrosis with enhanced safety via asymmetric inhibition of prolyl-tRNA synthetase 1. Embo Mol Med, 15:e16940-e16940, 2023 Cited by PubMed: 37212275 DOI: 10.15252/emmm.202216940 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation