7XQE
Crystal Structure of human RORgamma (C455E) LBD in complex with compound XY039
Summary for 7XQE
Entry DOI | 10.2210/pdb7xqe/pdb |
Descriptor | Nuclear receptor ROR-gamma, 2,4-difluoro-N-(1-((4-(trifluoromethyl)benzyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)benzenesulfonamide, GLYCEROL, ... (5 entities in total) |
Functional Keywords | ror gamma, lbd, inhibitor, dna binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 63673.26 |
Authors | |
Primary citation | Wu, X.S.,Luo, X.Y.,Li, C.C.,Zhao, X.F.,Zhang, C.,Chen, X.S.,Lu, Z.F.,Wu, T.,Yu, H.N.,Peng, C.,Hu, Q.Q.,Shen, H.,Xu, Y.,Zhang, Y. Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as ROR gamma inverse agonists against prostate cancer. Acta Pharmacol.Sin., 2024 Cited by PubMed: 38698214DOI: 10.1038/s41401-024-01274-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.57 Å) |
Structure validation
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