7XMD

Cryo-EM structure of Cytochrome bo3 from Escherichia coli, the structure complexed with an allosteric inhibitor N4

Summary for 7XMD

Entry DOI	10.2210/pdb7xmd/pdb
EMDB information	33294
Descriptor	Cytochrome bo(3) ubiquinol oxidase subunit 1, UNKNOWN ATOM OR ION, Ubiquinol oxidase subunit 2, ... (10 entities in total)
Functional Keywords	respiratory enzyme, membrane protein, heme protein, allosteric inhibitor, oxidoreductase
Biological source	Escherichia coli More
Total number of polymer chains	4
Total formula weight	148574.18
Authors	Nishida, Y.,Shigematsu, H.,Iwamoto, T.,Takashima, S.,Shintani, Y. (deposition date: 2022-04-25, release date: 2022-12-21, Last modification date: 2024-07-03)
Primary citation	Nishida, Y.,Yanagisawa, S.,Morita, R.,Shigematsu, H.,Shinzawa-Itoh, K.,Yuki, H.,Ogasawara, S.,Shimuta, K.,Iwamoto, T.,Nakabayashi, C.,Matsumura, W.,Kato, H.,Gopalasingam, C.,Nagao, T.,Qaqorh, T.,Takahashi, Y.,Yamazaki, S.,Kamiya, K.,Harada, R.,Mizuno, N.,Takahashi, H.,Akeda, Y.,Ohnishi, M.,Ishii, Y.,Kumasaka, T.,Murata, T.,Muramoto, K.,Tosha, T.,Shiro, Y.,Honma, T.,Shigeta, Y.,Kubo, M.,Takashima, S.,Shintani, Y. Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases. Nat Commun, 13:7591-7591, 2022 Cited by PubMed: 36481732 DOI: 10.1038/s41467-022-34771-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.99 Å)

Structure validation