7XGF

Crystal structure of BCL-xL in complex with computationally designed inhibitor protein

Summary for 7XGF

Entry DOI	10.2210/pdb7xgf/pdb
Related	7XGE
Descriptor	BCL-xL and MCL-1 dual inhibitor 2, BCL-xL (3 entities in total)
Functional Keywords	computational design, apotosis, de novo protein
Biological source	synthetic construct More
Total number of polymer chains	6
Total formula weight	115769.70
Authors	Oh, B.-H.,Kim, S. (deposition date: 2022-04-04, release date: 2022-07-20, Last modification date: 2024-04-03)
Primary citation	Kim, S.,Park, H.S.,Oh, B.H. Computational design of an apoptogenic protein that binds BCL-xL and MCL-1 simultaneously and potently. Comput Struct Biotechnol J, 20:3019-3029, 2022 Cited by PubMed: 35782728 DOI: 10.1016/j.csbj.2022.06.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation