7XBZ
Crystal structure of Staphylococcus aureus ClpP in complex with R-ZG197
Summary for 7XBZ
Entry DOI | 10.2210/pdb7xbz/pdb |
Descriptor | ATP-dependent Clp protease proteolytic subunit, (6S,9aS)-6-[(2S)-butan-2-yl]-8-[(1R)-1-naphthalen-1-ylethyl]-4,7-bis(oxidanylidene)-N-[4,4,4-tris(fluoranyl)butyl]-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | protease, hydrolase |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 14 |
Total formula weight | 309966.88 |
Authors | Wei, B.Y.,Gan, J.H.,Yang, C.-G. (deposition date: 2022-03-22, release date: 2022-11-16, Last modification date: 2023-11-29) |
Primary citation | Wei, B.,Zhang, T.,Wang, P.,Pan, Y.,Li, J.,Chen, W.,Zhang, M.,Ji, Q.,Wu, W.,Lan, L.,Gan, J.,Yang, C.G. Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP. Nat Commun, 13:6909-6909, 2022 Cited by PubMed: 36376309DOI: 10.1038/s41467-022-34753-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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