7WYX
Cryo-EM structure of Na+,K+-ATPase in the E2P state formed by ATP with istaroxime
Summary for 7WYX
Entry DOI | 10.2210/pdb7wyx/pdb |
Related | 7WYU 7WYV 7WYW 7WYY 7WYZ 7WZ0 |
EMDB information | 32897 |
Descriptor | Sodium/potassium-transporting ATPase subunit alpha, ADENOSINE-5'-TRIPHOSPHATE, (3E,5S,8R,9S,10R,13S,14S)-3-(2-azanylethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione, ... (14 entities in total) |
Functional Keywords | na+, k+-atpase, membrane protein, ion transport, transport protein |
Biological source | Squalus acanthias (spiny dogfish) More |
Total number of polymer chains | 6 |
Total formula weight | 348318.14 |
Authors | Kanai, R.,Cornelius, F.,Vilsen, B.,Toyoshima, C. (deposition date: 2022-02-16, release date: 2022-04-27) |
Primary citation | Kanai, R.,Cornelius, F.,Vilsen, B.,Toyoshima, C. Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids. Proc.Natl.Acad.Sci.USA, 119:e2123226119-e2123226119, 2022 Cited by PubMed: 35380894DOI: 10.1073/pnas.2123226119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
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