7WQS
Crystal structure of Aldo-keto reductase 1C3 complexed with compound 25
Summary for 7WQS
Entry DOI | 10.2210/pdb7wqs/pdb |
Descriptor | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(3-methoxyphenyl)benzamide, ... (4 entities in total) |
Functional Keywords | aldo-keto reductase, lipid metabolism, nad, nadp, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 77661.80 |
Authors | |
Primary citation | Liu, Y.,Chen, Y.,Jiang, J.,Chu, X.,Guo, Q.,Zhao, L.,Feng, F.,Liu, W.,Zhang, X.,He, S.,Yang, P.,Fang, P.,Sun, H. Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer. Eur.J.Med.Chem., 247:115013-115013, 2022 Cited by PubMed: 36566714DOI: 10.1016/j.ejmech.2022.115013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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