7WML
A novel chemical derivative(85) of THRB agonist
Summary for 7WML
Entry DOI | 10.2210/pdb7wml/pdb |
Descriptor | Isoform Beta-2 of Thyroid hormone receptor beta, Nuclear receptor coactivator 2, 2-[[7-[4-(3,5-dimethylphenyl)carbonyl-2,6-dimethyl-phenoxy]-1-ethoxy-4-oxidanyl-isoquinolin-3-yl]carbonylamino]ethanoic acid, ... (4 entities in total) |
Functional Keywords | transcription factor, ligand., transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 31303.15 |
Authors | |
Primary citation | Li, Q.,Yao, B.,Zhao, S.,Lu, Z.,Zhang, Y.,Xiang, Q.,Wu, X.,Yu, H.,Zhang, C.,Li, J.,Zhuang, X.,Wu, D.,Li, Y.,Xu, Y. Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist. J.Med.Chem., 65:7193-7211, 2022 Cited by PubMed: 35507418DOI: 10.1021/acs.jmedchem.2c00144 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.67 Å) |
Structure validation
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