7WM7
Threonyl-tRNA synthetase from Salmonella enterica in complex with an inhibitor
Summary for 7WM7
Entry DOI | 10.2210/pdb7wm7/pdb |
Descriptor | Threonine--tRNA ligase, ZINC ION, (2S,3R)-2-azanyl-N-[5-(7-bromanyl-6-chloranyl-4-oxidanylidene-quinazolin-3-yl)pentyl]-3-oxidanyl-N-[[3-(1-oxidanylidene-2,3-dihydroisoindol-5-yl)phenyl]methyl]butanamide, ... (4 entities in total) |
Functional Keywords | ligase-inhibitor complex, ligase/inhibitor |
Biological source | Salmonella enterica subsp. enterica serovar Cubana str. 76814 |
Total number of polymer chains | 2 |
Total formula weight | 97393.83 |
Authors | |
Primary citation | Cai, Z.,Chen, B.,Yu, Y.,Guo, J.,Luo, Z.,Cheng, B.,Xu, J.,Gu, Q.,Zhou, H. Design, Synthesis, and Proof-of-Concept of Triple-Site Inhibitors against Aminoacyl-tRNA Synthetases. J.Med.Chem., 65:5800-5820, 2022 Cited by PubMed: 35363470DOI: 10.1021/acs.jmedchem.2c00134 PDB entries with the same primary citation |
Experimental method |
Structure validation
Download full validation report