7WIT

Structure of SUR1 in complex with mitiglinide

Summary for 7WIT

• Entry DOI: 10.2210/pdb7wit/pdb
• EMDB information: 32535
• Descriptor: ATP-sensitive inward rectifier potassium channel 11,ATP-binding cassette sub-family C member 8 isoform X1, ADENOSINE-5'-TRIPHOSPHATE, (2S)-4-[(3aR,7aS)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-4-oxidanylidene-2-(phenylmethyl)butanoic acid (3 entities in total)
• Functional Keywords: sur1, katp, channel, mitiglinide, membrane protein
• Biological source: Bos taurus (cattle); More
• Total number of polymer chains: 1
• Total formula weight: 160262.43

Authors

Chen, L.,Wang, M.M. (deposition date: 2022-01-04, release date: 2022-11-16, Last modification date: 2024-06-26)

• Primary citation: Wang, M.M.,Wu, J.X.,Chen, L.; Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide; Front Pharmacol, 13:929684-929684, 2022; PubMed: 35847046; DOI: 10.3389/fphar.2022.929684

Experimental method

ELECTRON MICROSCOPY (3.21 Å)