7W1E
Crystal structure of Klebsiella pneumoniae K1 capsule-specific polysaccharide lyase in complex with products
This is a non-PDB format compatible entry.
Summary for 7W1E
| Entry DOI | 10.2210/pdb7w1e/pdb |
| Descriptor | K1 LYASE, 3-O-acetyl-6-deoxy-alpha-L-galactopyranose-(1-3)-beta-D-glucopyranose, IMIDAZOLE, ... (6 entities in total) |
| Functional Keywords | beta-helix; polysaccharide lyase; tail spike protein, lyase, viral protein |
| Biological source | Klebsiella phage NTUH-K2044-K1-1 |
| Total number of polymer chains | 6 |
| Total formula weight | 440610.84 |
| Authors | Tu, I.F.,Huang, K.F.,Wu, S.H. (deposition date: 2021-11-19, release date: 2022-05-18, Last modification date: 2024-05-29) |
| Primary citation | Tu, I.F.,Lin, T.L.,Yang, F.L.,Lee, I.M.,Tu, W.L.,Liao, J.H.,Ko, T.P.,Wu, W.J.,Jan, J.T.,Ho, M.R.,Chou, C.Y.,Wang, A.H.,Wu, C.Y.,Wang, J.T.,Huang, K.F.,Wu, S.H. Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use. J.Biomed.Sci., 29:9-9, 2022 Cited by PubMed Abstract: K1 capsular polysaccharide (CPS)-associated Klebsiella pneumoniae is the primary cause of pyogenic liver abscesses (PLA) in Asia. Patients with PLA often have serious complications, ultimately leading to a mortality of ~ 5%. This K1 CPS has been reported as a promising target for development of glycoconjugate vaccines against K. pneumoniae infection. The pyruvylation and O-acetylation modifications on the K1 CPS are essential to the immune response induced by the CPS. To date, however, obtaining the fragments of K1 CPS that contain the pyruvylation and O-acetylation for generating glycoconjugate vaccines still remains a challenge. PubMed: 35130876DOI: 10.1186/s12929-022-00792-4 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.46 Å) |
Structure validation
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