7VZZ
The structure of GdmN in complex with the natural tetrahedral intermediate, carbamoyl adenylate, and 20-O-methyl-19-chloroproansamitocin
Summary for 7VZZ
Entry DOI | 10.2210/pdb7vzz/pdb |
Descriptor | GdmN, 1,2-ETHANEDIOL, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl [(~{S})-azanyl-[[(5~{S},6~{E},8~{S},9~{S},12~{R},13~{E},15~{E})-21-chloranyl-12,20-dimethoxy-6,8,16-trimethyl-5-oxidanyl-3,11-bis(oxidanylidene)-2-azabicyclo[16.3.1]docosa-1(21),6,13,15,18(22),19-hexaen-9-yl]oxy]-oxidanyl-methyl] hydrogen phosphate, ... (8 entities in total) |
Functional Keywords | homodimer, carbamoyltransferase, ansamycins antibiotics, transferase |
Biological source | Streptomyces hygroscopicus |
Total number of polymer chains | 2 |
Total formula weight | 156429.48 |
Authors | |
Primary citation | Wei, J.,Zhang, X.,Zhou, Y.,Cheng, X.,Lin, Z.,Tang, M.,Zheng, J.,Wang, B.,Kang, Q.,Bai, L. Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies. Nat Commun, 13:6617-6617, 2022 Cited by PubMed: 36329057DOI: 10.1038/s41467-022-34387-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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