7VP9
Crystal structure of human ClpP in complex with ZG111
Summary for 7VP9
Entry DOI | 10.2210/pdb7vp9/pdb |
Descriptor | ATP-dependent Clp protease proteolytic subunit, mitochondrial, (6S,9aS)-N-[(4-bromophenyl)methyl]-6-[(2S)-butan-2-yl]-8-(naphthalen-1-ylmethyl)-4,7-bis(oxidanylidene)-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | mitochondrial protease, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 14 |
Total formula weight | 347084.21 |
Authors | Wang, P.Y.,Gan, J.H.,Yang, C.-G. (deposition date: 2021-10-15, release date: 2022-06-08, Last modification date: 2023-11-29) |
Primary citation | Wang, P.,Zhang, T.,Wang, X.,Xiao, H.,Li, H.,Zhou, L.L.,Yang, T.,Wei, B.,Zhu, Z.,Zhou, L.,Yang, S.,Lu, X.,Zhang, Y.,Huang, Y.,Gan, J.,Yang, C.G. Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma. Cell Chem Biol, 29:1396-1408.e8, 2022 Cited by PubMed: 35905743DOI: 10.1016/j.chembiol.2022.07.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.552 Å) |
Structure validation
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