7VM7
Crystal structure of inactive uPA in complex with nafamostat
Summary for 7VM7
| Entry DOI | 10.2210/pdb7vm7/pdb |
| Descriptor | Urokinase-type plasminogen activator chain B, (6-carbamimidoylnaphthalen-2-yl) 4-carbamimidamidobenzoate (3 entities in total) |
| Functional Keywords | upa, serine protease, nafamostat, hydrolase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 27917.79 |
| Authors | Jiang, L.G.,Huang, M.D. (deposition date: 2021-10-07, release date: 2022-11-23, Last modification date: 2023-11-29) |
| Primary citation | Zhou, Y.,Wu, J.,Xue, G.,Li, J.,Jiang, L.,Huang, M. Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat. Biophys.J., 121:3940-3949, 2022 Cited by PubMed: 36039386DOI: 10.1016/j.bpj.2022.08.034 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
Download full validation report
