7V1U
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZJ12
Summary for 7V1U
Entry DOI | 10.2210/pdb7v1u/pdb |
Descriptor | Bromodomain-containing protein 4, ~{N}-(3-ethyl-6-methoxy-1,2-benzoxazol-5-yl)-2-methoxy-benzenesulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | brd4(1), bromodomain, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 17191.79 |
Authors | |
Primary citation | Zhang, M.F.,Luo, X.Y.,Zhang, C.,Wang, C.,Wu, X.S.,Xiang, Q.P.,Xu, Y.,Zhang, Y. Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia. Acta Pharmacol.Sin., 43:2735-2748, 2022 Cited by PubMed: 35264812DOI: 10.1038/s41401-022-00881-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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