7UZ1
Structure of beta-glycosidase from Sulfolobus solfataricus in complex with C5a-bromo-valienide.
Summary for 7UZ1
Entry DOI | 10.2210/pdb7uz1/pdb |
Descriptor | Beta-galactosidase, (1R,2S,3R,4R)-5-bromo-6-(hydroxymethyl)cyclohex-5-ene-1,2,3,4-tetrol, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | covalent inhibition, glycoside hydrolase, hydrolase |
Biological source | Saccharolobus solfataricus |
Total number of polymer chains | 2 |
Total formula weight | 114225.12 |
Authors | Danby, P.M.,Jeong, A.,Sim, L.,Sweeney, R.P.,Wardman, J.F.,Karimi, R.,Geissner, A.,Worrall, L.J.,Strynadka, N.C.J.,Withers, S.G. (deposition date: 2022-05-08, release date: 2023-04-05, Last modification date: 2023-10-25) |
Primary citation | Danby, P.M.,Jeong, A.,Sim, L.,Sweeney, R.P.,Wardman, J.F.,Karimi, R.,Geissner, A.,Worrall, L.J.,Reid, J.P.,Strynadka, N.C.J.,Withers, S.G. Vinyl Halide-Modified Unsaturated Cyclitols are Mechanism-Based Glycosidase Inhibitors. Angew.Chem.Int.Ed.Engl., 62:e202301258-e202301258, 2023 Cited by PubMed: 36940280DOI: 10.1002/anie.202301258 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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