7UMP
CRYSTAL STRUCTURE OF PHD2 CATALYTIC DOMAIN (CID 7465) IN COMPLEX WITH AKB-6548 AT 1.8 A RESOLUTION
Summary for 7UMP
Entry DOI | 10.2210/pdb7ump/pdb |
Descriptor | Egl nine homolog 1, FE (II) ION, Vadadustat, ... (5 entities in total) |
Functional Keywords | egln1, phd2, metal binding protein, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 24752.42 |
Authors | Davie, D.R.,Abendroth, J.,Boyd, J. (deposition date: 2022-04-07, release date: 2022-05-18, Last modification date: 2023-10-25) |
Primary citation | Zuk, A.,Si, Z.,Loi, S.,Bommegowda, S.,Hoivik, D.,Danthi, S.,Molnar, G.,Csizmadia, V.,Rabinowitz, M. Preclinical Characterization of Vadadustat (AKB-6548), an Oral Small Molecule Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, for the Potential Treatment of Renal Anemia. J.Pharmacol.Exp.Ther., 383:11-24, 2022 Cited by PubMed: 35926869DOI: 10.1124/jpet.122.001126 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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