7TYZ

Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin

Summary for 7TYZ

Entry DOI	10.2210/pdb7tyz/pdb
EMDB information	26200
Descriptor	Spike glycoprotein, DARPin FSR22, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	darpins, anti-sars-cov-2, therapeutics, covid-19, viral protein-antiviral protein complex, viral protein/antiviral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	6
Total formula weight	499783.88
Authors	Kwon, Y.D.,Gorman, J.,Kwong, P.D. (deposition date: 2022-02-15, release date: 2022-12-07, Last modification date: 2023-03-15)
Primary citation	Chonira, V.,Kwon, Y.D.,Gorman, J.,Case, J.B.,Ku, Z.,Simeon, R.,Casner, R.G.,Harris, D.R.,Olia, A.S.,Stephens, T.,Shapiro, L.,Bender, M.F.,Boyd, H.,Teng, I.T.,Tsybovsky, Y.,Krammer, F.,Zhang, N.,Diamond, M.S.,Kwong, P.D.,An, Z.,Chen, Z. A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins. Nat.Chem.Biol., 19:284-291, 2023 Cited by PubMed: 36411391 DOI: 10.1038/s41589-022-01193-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.51 Å)

Structure validation