7TD4
Sphingosine-1-phosphate receptor 1-Gi complex bound to Siponimod
Summary for 7TD4
Entry DOI | 10.2210/pdb7td4/pdb |
EMDB information | 25823 |
Descriptor | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | gpcr, complex, lipid, membrane protein |
Biological source | Bos taurus (cattle) More |
Total number of polymer chains | 4 |
Total formula weight | 133101.61 |
Authors | Liu, S.,Paknejad, N.,Zhu, L.,Kihara, Y.,Ray, D.,Chun, J.,Liu, W.,Hite, R.K.,Huang, X.Y. (deposition date: 2021-12-30, release date: 2022-02-09, Last modification date: 2022-02-23) |
Primary citation | Liu, S.,Paknejad, N.,Zhu, L.,Kihara, Y.,Ray, M.,Chun, J.,Liu, W.,Hite, R.K.,Huang, X.Y. Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13:731-731, 2022 Cited by PubMed: 35136060DOI: 10.1038/s41467-022-28417-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.6 Å) |
Structure validation
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