7TAS

SARS-CoV-2 spike in complex with the S2K146 neutralizing antibody Fab fragment (local refinement of the RBD and S2K146)

Summary for 7TAS

• Entry DOI: 10.2210/pdb7tas/pdb
• EMDB information: 25783
• Descriptor: S2K146 Fab heavy chain, S2K146 Fab light chain, Spike glycoprotein, ... (4 entities in total)
• Functional Keywords: sars-cov-2, covid-19, spike glycoprotein, fusion protein, neutralizing antibodies, structural genomics, seattle structural genomics center for infectious disease, ssgcid, inhibitor, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 167655.25

Authors

Park, Y.J.,Veesler, D.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2021-12-21, release date: 2022-01-12, Last modification date: 2022-02-09)

• Primary citation: Park, Y.J.,De Marco, A.,Starr, T.N.,Liu, Z.,Pinto, D.,Walls, A.C.,Zatta, F.,Zepeda, S.K.,Bowen, J.E.,Sprouse, K.R.,Joshi, A.,Giurdanella, M.,Guarino, B.,Noack, J.,Abdelnabi, R.,Foo, S.C.,Rosen, L.E.,Lempp, F.A.,Benigni, F.,Snell, G.,Neyts, J.,Whelan, S.P.J.,Virgin, H.W.,Bloom, J.D.,Corti, D.,Pizzuto, M.S.,Veesler, D.; Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry.; Science, 375:449-454, 2022; PubMed: 34990214; DOI: 10.1126/science.abm8143

Experimental method

ELECTRON MICROSCOPY (3.2 Å)