7T5Z
P. aeruginosa LpxA in complex with ligand L8
Summary for 7T5Z
Entry DOI | 10.2210/pdb7t5z/pdb |
Descriptor | Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, (4S)-N-(1H-tetrazol-5-yl)-2-[3-(trifluoromethyl)benzene-1-sulfonyl]-1,2,3,4-tetrahydroisoquinoline-4-carboxamide, DI(HYDROXYETHYL)ETHER, ... (4 entities in total) |
Functional Keywords | lpxa, lipid a, lps, lipopolysaccharide, udp-n-acetylglucosamine o-acyltransferase, transferase |
Biological source | Pseudomonas aeruginosa PA7 |
Total number of polymer chains | 6 |
Total formula weight | 171112.96 |
Authors | |
Primary citation | Sacco, M.D.,Defrees, K.,Zhang, X.,Lawless, W.,Nwanochie, E.,Balsizer, A.,Darch, S.E.,Renslo, A.R.,Chen, Y. Structure-Based Ligand Design Targeting Pseudomonas aeruginosa LpxA in Lipid A Biosynthesis. Acs Infect Dis., 8:1231-1240, 2022 Cited by PubMed: 35653508DOI: 10.1021/acsinfecdis.1c00650 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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